Does DUO SSO support multiple 365 tenants, 1 active directory in one DUO account?

We have multiple 365 tenants in our company that sync from 1 on-prem active directory. Think 1 OU per 365 tenant that gets synced back and forth.

SO we have 1 DUO account with our AuthProxy servers that sync our 1 AD by Groups. 1 group per OU (department) of users.

Can we create multiple DUO Sync apps per tenant, or can this work at all?

Currently we are doing this via ADFS /DUO, but we would like to move away from ADFS.